Co-Transcriptional Splicing and Functional Role of PKCβ in Insulin-Sensitive L6 Skeletal Muscle Cells and 3T3-L1 Adipocytes
PKC βII is alternatively spliced during acute insulin stimulation in L6 skeletal muscle cells. This PKC βII isoform is critical in propagating GLUT4 translocation. PKC β protein and promoter dysfunction correlate with human insulin resistance. TZD treatment ameliorates whole-body insulin-resistance....
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| Format: | Others |
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Scholar Commons
2009
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| Online Access: | http://scholarcommons.usf.edu/etd/3688 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=4890&context=etd |