Design and Synthesis of Beta-Hairpin Peptidomimetics for Modulating Integrin Mediated Cell Adhesion, Abeta Fibrillogenesis and p53-MDM2 Protein-Protein Interactions
Inhibiting therapeutically important protein-protein interactions has been a tremendous challenge for medicinal chemists. The folded 3D structures of peptides and proteins, mainly comprise secondary structural elements i.e α-helices and β-sheet have created an opportunity to design small molecules a...
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| Format: | Others |
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Scholar Commons
2010
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| Online Access: | http://scholarcommons.usf.edu/etd/3458 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=4653&context=etd |