Promoting and preventing alzheimer's disease in a transgenic mouse model: Apolipoprotein e and environmental enrichment
Besides age, inheritance of the apoE-E4 allele is the main risk factor for late-onset AD. To determine the role of apoE in amyloid deposition, we studied mice expressing both mutant human amyloid [beta]-protein precursor (APP) and presenilin 1 (PS1) that were either normal or knocked-out for apoE. B...
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| Format: | Others |
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Scholar Commons
2005
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| Online Access: | http://scholarcommons.usf.edu/etd/2835 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=3834&context=etd |