Substrate-Based Inhibitors of Peptidylglycine á-Amidating Monooxygenase (PAM) as Anti-Proliferative Drugs for Cancer
C-Terminal glycine-extended prohormones are enzymatically converted to á-amidated peptides, by peptidylglycine á-amidating monooxygenase (PAM). PAM is a bifunctional enzyme with two catalytic domains: peptidylglycine á-hydroxylating monooxygenase (PHM) and peptidylglycine peptidylglycineaminoglycola...
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| Format: | Others |
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Scholar Commons
2003
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| Online Access: | https://scholarcommons.usf.edu/etd/1341 https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=2340&context=etd |