Substrate-Based Inhibitors of Peptidylglycine á-Amidating Monooxygenase (PAM) as Anti-Proliferative Drugs for Cancer

Substrate-Based Inhibitors of Peptidylglycine á-Amidating Monooxygenase (PAM) as Anti-Proliferative Drugs for Cancer

C-Terminal glycine-extended prohormones are enzymatically converted to á-amidated peptides, by peptidylglycine á-amidating monooxygenase (PAM). PAM is a bifunctional enzyme with two catalytic domains: peptidylglycine á-hydroxylating monooxygenase (PHM) and peptidylglycine peptidylglycineaminoglycola...

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Bibliographic Details
Main Author: Chew, Geoffrey H
Format: Others
Published: Scholar Commons 2003
Subjects:
enzyme
prostate
inhibition
4-hpr
kinetics
American Studies
Arts and Humanities
Online Access:https://scholarcommons.usf.edu/etd/1341
https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=2340&context=etd

Internet

https://scholarcommons.usf.edu/etd/1341
https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=2340&context=etd

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