Modification of MDMX by Ubiquitination and Sumoylation
MDM2 and MDMX are two major negative regulators of tumor suppressor p53. Both MDM2 and MDMX can inactivate p53 and play important roles in mouse embryonic development in a p53 dependent manner. MDM2 possesses ubiquitin E3 ligase activity and mediates self-ubiquitination as well as ubiquitination and...
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Scholar Commons
2005
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| Online Access: | https://scholarcommons.usf.edu/etd/806 https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=1805&context=etd |