Roles of amino acids in the food effect : metabolic and pharmacokinetic studies on propafenone and metoprolol
The bioavailability of some high hepatic first-pass drugs has been shown to increase substantially when they are orally administered with a protein-rich meal in humans. A change in hepatic metabolic capacity, induced by dietary amino acids (AAs), could be the cause of the food effect. The purpose of...
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| Format: | Others |
| Language: | en |
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University of Saskatchewan
2000
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| Online Access: | http://library.usask.ca/theses/available/etd-10212004-002828 |