Anti-apoptotic actions of R-2HMP in cerebellar granule cells : changes of mitochondrial membrane potential and sub-cellular GAPDH protein
(R)-'N'-(2-heptyl)-'N'-methylpropargylamine (R-2HMP) has been shown to reduce neuronal death through an action at the same site as R-deprenyl: this site has been proposed to be glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Using cultured cerebellar granule cells, two modes of...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en |
| Published: |
University of Saskatchewan
2001
|
| Online Access: | http://library.usask.ca/theses/available/etd-10212004-002323 |