Developing strategies to re-activate epigenetically silenced tumor suppressor genes in acute myeloid leukemia
Epigenetic mechanisms are essential for normal cell development. Alteration in those normal processes leads to malignant cell transformation and with this to cancer development. Use of inhibitors that alter the epigenetics of DNA methylation and histone post translational modifications has lead to t...
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| Format: | Others |
| Language: | en |
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University of Saskatchewan
2011
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| Online Access: | http://library.usask.ca/theses/available/etd-01112011-165701/ |