Secoisolariciresinol (SECO) analogues: oxidative metabolism, cytochrome P450 inhibition and implications for toxicity

Secoisolariciresinol (SECO) analogues: oxidative metabolism, cytochrome P450 inhibition and implications for toxicity

Secoisolariciresinol (SECO) is the major lignan present in flaxseed, but unlike the structurally related lignan nordihydroguaiaretic acid, it is not associated with toxicity. The major phase I metabolite of SECO is lariciresinol, likely formed as a result of para-quinone methide (p-QM) formation fol...

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Bibliographic Details
Other Authors: Krol, Ed S.
Language:English
Published: 2016
Subjects:
secoisolariciresinol
lignans
xenobiotic metabolism
quinones
reactive metabolites
glutathione conjugates
hepatotoxicity
Online Access:http://hdl.handle.net/10388/ETD-2016-02-2434

Internet

http://hdl.handle.net/10388/ETD-2016-02-2434

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