Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism

Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism

Nordihydroguaiaretic acid (NDGA), is a naturally-occurring lignan isolated from the creosote bush (Larrea tridentata). The aqueous extract of this shrub, commonly referred to as Chaparral tea, was listed in the American pharmacopeia as an ethnobotanical used to treat tuberculosis, arthritis and canc...

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Bibliographic Details
Other Authors: Krol, Edward S.
Language:English
Published: 2016
Subjects:
nordihydroguaiaretic aci
lignans
dibenzocyclooctadiene
autoxidation
cyclization
bioactivation
reactive metabolites
glutathione adducts
liquid chromatography–tandem mass spectrometry (LC–MS/MS)
multiple reactions monitoring (MRM)
neutral loss (NL)
precursor ion (PI).
Online Access:http://hdl.handle.net/10388/ETD-2015-06-1915

Internet

http://hdl.handle.net/10388/ETD-2015-06-1915

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