miR-122 binding of Hepatitis C virus 5'untranslated region augments the HCV life cycle independent from the p-body protein DDX6, and represents a novel target for siRNA targeted therapy
Generally Hepatitis C Virus tropism is limited to hepatocytes. This limited tropism is a result of the receptors HCV requires for cellular entry and other host cellular factors including, uniquely, a liver specific miRNA, miR-122. The relationship between HCV and miR-122 is interesting, as commonly...
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| Language: | English |
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2015
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| Online Access: | http://hdl.handle.net/10388/ETD-2014-08-1657 |