Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide

Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide

This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C. Two methods for the synthesis of 11C-labelled acrylamides have been explored. First, [1-11C]-acrylic acid was obtained from a palladium(0)-mediated 11C-carboxylation of acetylene w...

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Bibliographic Details
Main Author: Åberg, Ola
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för biokemi och organisk kemi 2009
Subjects:
[11C]carbon monoxide
isotopic labelling
PET
acrylamide
EGFR
VEGFR-2
11C
Organic chemistry
Organisk kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98599
http://nbn-resolving.de/urn:isbn:978-91-554-7451-5

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98599
http://nbn-resolving.de/urn:isbn:978-91-554-7451-5

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