MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen...

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Bibliographic Details
Main Author: Mokhtari, Dariush
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för medicinsk cellbiologi 2008
Subjects:
Cell biology
MEKK-1
JNK
human islets
β-cells
siRNA
apoptosis
cell death
MAPK
nitric oxide
cytokines
streptozotocin
c-Rel
NF-κB
Cellbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8896
http://nbn-resolving.de/urn:isbn:978-91-554-7222-1

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8896
http://nbn-resolving.de/urn:isbn:978-91-554-7222-1

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