Glucotoxicity in Insulin-Producing β-Cells

Glucotoxicity in Insulin-Producing β-Cells

<b>Background and aims:</b> Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study. <b>Materials and...

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Bibliographic Details
Main Author: Nyblom, Hanna K
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för medicinsk cellbiologi 2007
Subjects:
Cell biology
type 2 diabetes
SELDI-TOF MS
glucotoxicity
proteomics
insulin secretion
mitochondria
lipids
INS-1E cells
GC-MS
HR-MAS NMR
metabolomics
human islet
AMPK
AICAR
ER stress
apoptosis
Cellbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8309
http://nbn-resolving.de/urn:isbn:978-91-554-7022-7

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8309
http://nbn-resolving.de/urn:isbn:978-91-554-7022-7

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