Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

The DDT metabolite 3-methylsulphonyl-DDE (3-MeSO2-DDE) induces cell death specifically in the adrenal cortex of mice after a cytochrome P45011B1 (CYP11B1)-catalysed bioactivation. This substance is not only an environmental pollutant, but also a suggested lead compound for an improved chemotherapy o...

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Bibliographic Details
Main Author: Lindström, Veronica
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Ekotoxikologi 2007
Subjects:
Toxicology
3-methylsulphonyl-DDE
o
p'-DDD
CYP11B1
adrenal cortex
tissue-specific toxicity
bioactivation
kinetics
Y-1 cells
Toxikologi
Biology
Biologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8180
http://nbn-resolving.de/urn:isbn:978-91-554-6950-4

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8180
http://nbn-resolving.de/urn:isbn:978-91-554-6950-4

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