Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides

Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides

Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to c...

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Bibliographic Details
Main Author: Rönn, Robert
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för läkemedelskemi 2007
Subjects:
Pharmaceutical chemistry
hepatitis C virus
HCV
NS3 protease inhibitor
acyl sulfonamide
bioisostere
palladium
carbonylation
microwave
molybdenum hexacarbonyl
Farmaceutisk kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7814
http://nbn-resolving.de/urn:isbn:978-91-554-6862-0

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7814
http://nbn-resolving.de/urn:isbn:978-91-554-6862-0

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