Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering

Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering

The glutathione transferases (GSTs) represent a superfamily of dimeric proteins involved in cellular detoxication by catalyzing the nucleophilic addition of the reduced glutathione (GSH) to the hydrophobic electrophiles. The present work focuses on the functional role of the conserved structures of...

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Bibliographic Details
Main Author: Hegazy, Usama M.
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för naturvetenskaplig biokemi 2006
Subjects:
Biochemistry
Glutathione transferase
targeted chemical modification
lock-and-key motif
cooperativity
stucture-function relationship
protein engineering
unnatural amino acid
site-specific mutation
Biokemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7146
http://nbn-resolving.de/urn:isbn:91-554-6654-0

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7146
http://nbn-resolving.de/urn:isbn:91-554-6654-0

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