Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. However, the HIV-...

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Bibliographic Details
Main Author: Ekegren, Jenny
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för läkemedelskemi 2006
Subjects:
Chemistry
HIV/AIDS
HIV-1 protease inhibitor
transition-state mimic
tertiary alcohol
palladium
cross-coupling
aminocarbonylation
microwave
molybdenum hexacarbonyl
Kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6737
http://nbn-resolving.de/urn:isbn:91-554-6512-9

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6737
http://nbn-resolving.de/urn:isbn:91-554-6512-9

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