Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis
The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treat...
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| Format: | Doctoral Thesis |
| Language: | English |
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Uppsala universitet, Institutionen för läkemedelskemi
2001
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-657 http://nbn-resolving.de/urn:isbn:91-554-5017-2 |