Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. It w...

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Bibliographic Details
Main Author: Neuhoff, Sibylle
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2005
Subjects:
Pharmacy
Caco-2 cells
membrane permeability
drug permeation
drug efflux ratios
drug uptake ratios
Cremophor EL
bovine serum albumin
pH-dependent permeability
drug transport
FARMACI
PHARMACY
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5814
http://nbn-resolving.de/urn:isbn:91-554-6262-6

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5814
http://nbn-resolving.de/urn:isbn:91-554-6262-6

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