Involvement of Membrane Transport Proteins in Intestinal Absorption and Hepatic Disposition of Drugs Using Fexofenadine as a Model Drug

Involvement of Membrane Transport Proteins in Intestinal Absorption and Hepatic Disposition of Drugs Using Fexofenadine as a Model Drug

The aims of this thesis were to study the in vivo relevance of membrane transporters for intestinal absorption and the hepatic disposition of drugs in humans and preclinical models. Fexofenadine is a substrate for ABCB1 (P-glycoprotein) and members of the organic anion transporting polypeptide (OATP...

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Bibliographic Details
Main Author: Petri, Niclas
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2005
Subjects:
Biopharmacy
Fexofenadine
OATP
P-glycoprotein
Organic Anion Transporters
ATP-Binding Cassette Transporters
membrane transport proteins
Bioavailability
Biopharmaceutics
Biofarmaci
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5808
http://nbn-resolving.de/urn:isbn:91-554-6257-X

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5808
http://nbn-resolving.de/urn:isbn:91-554-6257-X

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