Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a c...

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Bibliographic Details
Main Author: Wannberg, Johan
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Avdelningen för organisk farmaceutisk kemi 2005
Subjects:
Pharmaceutical chemistry
HIV
protease inhibitors
palladium
carbonylations
molybdenum hexacarbonyl
dihydropyrimidone
DHPM
microwave
cross-coupling
diazylhydrazines
carbon monoxide
synthesis
C2-symmetric
HIV-1 protease inhibitors
aminocarbonylation
fluorous
Farmaceutisk kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5804
http://nbn-resolving.de/urn:isbn:91-554-6254-5

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5804
http://nbn-resolving.de/urn:isbn:91-554-6254-5

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