Intestinal Permeability and Presystemic Extraction of Fexofenadine and R/S-verapamil
The main objective of this thesis was to investigate the in vivo relevance of membrane transporters and cytochrome P450 (CYP) 3A4-mediated metabolism in the intestine and liver for the bioavailability of drugs in humans after oral administration. In the first part of the thesis, the main transport m...
Main Author: | Tannergren, Christer |
---|---|
Format: | Doctoral Thesis |
Language: | English |
Published: |
Uppsala universitet, Institutionen för farmaci
2004
|
Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3971 http://nbn-resolving.de/urn:isbn:91-554-5856-4 |
Similar Items
-
Involvement of Membrane Transport Proteins in Intestinal Absorption and Hepatic Disposition of Drugs Using Fexofenadine as a Model Drug
by: Petri, Niclas
Published: (2005) -
Dose Adaptation Based on Pharmacometric Models
by: Wallin, Johan
Published: (2009) -
Short-chain retinol dehydrogenases/reductases : Involvement in retinoid metabolism and expression in embryonic and adult mouse
by: Tuvendal, Paulina
Published: (2000) -
Cytochrome P450 enzymes in oxygenation of prostaglandin endoperoxides and arachidonic acid : Cloning, expression and catalytic properties of CYP4F8 and CYP4F21
by: Bylund, Johan
Published: (2000) -
Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives
by: Norlin, Maria
Published: (2000)