Intestinal Permeability and Presystemic Extraction of Fexofenadine and R/S-verapamil

Intestinal Permeability and Presystemic Extraction of Fexofenadine and R/S-verapamil

The main objective of this thesis was to investigate the in vivo relevance of membrane transporters and cytochrome P450 (CYP) 3A4-mediated metabolism in the intestine and liver for the bioavailability of drugs in humans after oral administration. In the first part of the thesis, the main transport m...

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Bibliographic Details
Main Author: Tannergren, Christer
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2004
Subjects:
Biopharmacy
Bioavailability
Fexofenadine
Verapamil
P-glycoprotein
CYP3A4
OATP
Enantioselective
Permeability
Caco-2
Intestinal perfusion
Biofarmaci
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3971
http://nbn-resolving.de/urn:isbn:91-554-5856-4

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3971
http://nbn-resolving.de/urn:isbn:91-554-5856-4

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