Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery

Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery

Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the dr...

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Bibliographic Details
Main Author: Hägerström, Helene
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2003
Subjects:
Pharmaceutics
gel
rheology
mucoadhesion
mucosal drug delivery
in situ gel
gellan gum
Carbopol
tensile strength
nasal mucosa
intranasal administration
dielectric spectroscopy
Galenisk farmaci
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3538
http://nbn-resolving.de/urn:isbn:91-554-5705-3

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3538
http://nbn-resolving.de/urn:isbn:91-554-5705-3

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