Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could...

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Bibliographic Details
Main Author: Andersson, Annika K.
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för medicinsk cellbiologi 2003
Subjects:
Cell biology
β-cell
Cyclooxygenase
Cytokine
Diabetes
IFN-γ
IL-1β
iNOS
Insulin
Melatonin
Nitric oxide
Pancreatic islets
Phospholipase D
Prostaglandin E2
Streptozotocin
Cellbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3537
http://nbn-resolving.de/urn:isbn:91-554-5704-5

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3537
http://nbn-resolving.de/urn:isbn:91-554-5704-5

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