The Multifunctional HnRNP A1 Protein in the Regulation of the Cyp2a5 Gene : Connecting Transcriptional and Posttranscriptional Processes

The Multifunctional HnRNP A1 Protein in the Regulation of the Cyp2a5 Gene : Connecting Transcriptional and Posttranscriptional Processes

The mouse xenobiotic-inducible Cyp2a5 gene is both transcriptionally and posttranscriptionally regulated. One of the most potent Cyp2a5 inducers, the hepatotoxin pyrazole, increases the CYP2A5 mRNA half-life. The induction is accomplished through the interaction of a pyrazole-inducible protein with...

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Bibliographic Details
Main Author: Glisovic, Tina
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2003
Subjects:
Pharmaceutical biochemistry
Cyp2a5
DNA-protein interaction
gene regulation
hnRNP A1
nucleocytoplasmic shuttling
RNA-protein interaction
RNA stabilization
posttranscriptional
transcriptional
Farmaceutisk biokemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3412
http://nbn-resolving.de/urn:isbn:91-554-5603-0

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3412
http://nbn-resolving.de/urn:isbn:91-554-5603-0

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