Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug dev...

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Bibliographic Details
Main Author: Novakovic, Ana M.
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2017
Subjects:
nonlinear mixed-effects models
pharmacometrics
NONMEM
multiple sclerosis
cladribine
EDSS
item response theory
relapse rate
absolute lymphocyte count
total volume T2 lesions
burden of disease
power
sample size
Pharmaceutical Sciences
Farmaceutisk vetenskap
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316562
http://nbn-resolving.de/urn:isbn:978-91-554-9836-8

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316562
http://nbn-resolving.de/urn:isbn:978-91-554-9836-8

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