Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, bu...

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Bibliographic Details
Main Author: Yngman, Gunnar
Format: Others
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2015
Subjects:
pharmacometrics
pharmacokinetics
PK
population pharmacokinetics
optimal design
FDC
fixed-dose combination
pediatrics
tuberculosis
rifampicin
pyrazinamide
isoniazid
ethambutol
modeling
simulation
estimation
allometric scaling
stochastical simulation and estimation
NONMEM
MATLAB
FO
FOCE
Expectation-Maximization algorithm
importance sampling
Nelder-Mead method
logistic function
discontinuity
euclidean distance
Sammon mapping
global minimum
local minima
Pharmaceutical Sciences
Farmaceutiska vetenskaper
Bioinformatics (Computational Biology)
Bioinformatik (beräkningsbiologi)
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242059

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242059

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