A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breas...

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Main Authors: Coviello, Andrea D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimaki, Terho, Keildson, Sarah, Lunetta, Kathryn L., He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Mei, Yong, Koster, Annemarie, Lohman, Kurt, Lyytikainen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R., Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania, Biffar, Reiner, Brabant, Georg, Cox, David G., Chen, Yuhui, Cummings, Steven, Ferrucci, Luigi, Gunter, Marc J., Hankinson, Susan E., Martikainen, Hannu, Hofman, Albert, Homuth, Georg, Illig, Thomas, Jansson, John-Olov, Johnson, Andrew D., Karasik, David, Karlsson, Magnus, Kettunen, Johannes, Kiel, Douglas P., Kraft, Peter, Liu, Jingmin, Ljunggren, Östen, Lorentzon, Mattias, Maggio, Marcello, Markus, Marcello R. P., Mellstrom, Dan, Miljkovic, Iva, Mirel, Daniel, Nelson, Sarah, Papunen, Laure Morin, Peeters, Petra H. M., Prokopenko, Inga, Raffel, Leslie, Reincke, Martin, Reiner, Alex P., Rexrode, Kathryn, Rivadeneira, Fernando, Schwartz, Stephen M., Siscovick, David, Soranzo, Nicole, Stockl, Doris, Tworoger, Shelley, Uitterlinden, Andre G., van Gils, Carla H., Vasan, Ramachandran S., Wichmann, H. -Erich, Zhai, Guangju, Bhasin, Shalender, Bidlingmaier, Martin, Chanock, Stephen J., De Vivo, Immaculata, Harris, Tamara B., Hunter, David J., Kahonen, Mika, Liu, Simin, Ouyang, Pamela, Spector, Tim D., van der Schouw, Yvonne T., Viikari, Jorma, Wallaschofski, Henri, McCarthy, Mark I., Frayling, Timothy M., Murray, Anna, Franks, Steve, Jarvelin, Marjo-Riitta, de Jong, Frank H., Raitakari, Olli, Teumer, Alexander, Ohlsson, Claes, Murabito, Joanne M., Perry, John R. B.
Format: Others
Language:English
Published: Uppsala universitet, Metabola bensjukdomar 2012
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181141