Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate...

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Bibliographic Details
Main Author: Carlert, Sara
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2012
Subjects:
gastrointestinal precipitation
crystallization
crystal nucleation
crystal growth
classical nucleation theory
poorly soluble drugs
drug absorption
biopharmaceutics classification system
in vitro/in vivo correlations (IVIVC)
in silico prediction
human intestinal fluid
dog intestinal fluid
simulated intestinal fluid
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178053
http://nbn-resolving.de/urn:isbn:978-91-554-8408-8

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178053
http://nbn-resolving.de/urn:isbn:978-91-554-8408-8

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