Generation of mutated expression plasmid KRT1 and comparison of HaCaT cells transfected with expression plasmid KRT1 or KRT10 concerning keratin aggregates
Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and pro...
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| Format: | Others |
| Language: | Swedish |
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Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi
2012
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-176426 |