Regulation of TGF-β Signaling by Post-Translational Modifications

Regulation of TGF-β Signaling by Post-Translational Modifications

Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription...

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Bibliographic Details
Main Author: Lönn, Peter
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Ludwiginstitutet för cancerforskning 2010
Subjects:
TGF-β
Smad
PARP-1
PARG
ALK5
SIK
signal transduction
transcription
post-translational modification
phosphorylation
ubiquitin
ADP-ribosylation
DNA-binding
receptor degradation
Cell and molecular biology
Cell- och molekylärbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128855
http://nbn-resolving.de/urn:isbn:978-91-554-7844-5

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128855
http://nbn-resolving.de/urn:isbn:978-91-554-7844-5

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