Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

The Arctic mutation in the Amyloid-β (Aβ) domain of the Amyloid-β precursor protein (APP) causes Alzheimer’s disease (AD) and confers unique biochemical characteristics to Aβ peptides. The aims of this thesis were to evaluate a transgenic model with the Arctic mutation, and to use it to gain new ins...

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Bibliographic Details
Main Author: Philipson, Ola
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap 2010
Subjects:
Alzheimer’s disease
Amyloid
Amyloid-β
intraneuronal
transgenic mice
immunohistochemistry
ELISA
Public health medicine research areas
Folkhälsomedicinska forskningsområden
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120919
http://nbn-resolving.de/urn:isbn:978-91-554-7810-0

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120919
http://nbn-resolving.de/urn:isbn:978-91-554-7810-0

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