Molecular Genetic Analysis in B-cell Lymphomas : A Focus on the p53 Pathway and p16INK4a

Molecular Genetic Analysis in B-cell Lymphomas : A Focus on the p53 Pathway and p16INK4a

The presence of TP53 mutations has been associated with inferior outcome in diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). In DLBCL, the impact of the TP53 codon 72 polymorphism and MDM2 SNP309 has not been clearly elucidated, whereas MDM2 SNP309 was suggested as a poo...

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Bibliographic Details
Main Author: Zainuddin, Norafiza
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi 2010
Subjects:
Diffuse large B-cell lymphoma
chronic lymphocytic leukemia
TP53 mutation
MDM2 SNP309
codon 72 polymorphism
p16INK4a methylation
Clinical genetics
Klinisk genetik
Molecular biology
Molekylärbiologi
Haematology
Hematologi
Tumour biology
Tumörbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113970
http://nbn-resolving.de/urn:isbn:978-91-554-7729-5

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113970
http://nbn-resolving.de/urn:isbn:978-91-554-7729-5

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