Oscillatory Signaling and Insulin Secretion from Single ß-cells

Oscillatory Signaling and Insulin Secretion from Single ß-cells

cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP sign...

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Bibliographic Details
Main Author: Idevall Hagren, Olof
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för medicinsk cellbiologi 2010
Subjects:
cAMP
Ca2+
oscillations
beta-cell
insulin secretion
evanescent wave microscopy
PIP3
PKA
Epac
Medical cell biology
Medicinsk cellbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113686
http://nbn-resolving.de/urn:isbn:978-91-554-7718-9

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113686
http://nbn-resolving.de/urn:isbn:978-91-554-7718-9

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