Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. Roll compaction is a complex process that depends on many factors, such as feed powd...

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Bibliographic Details
Main Author: Souihi, Nabil
Format: Doctoral Thesis
Language:English
Published: Umeå universitet, Kemiska institutionen 2014
Subjects:
Roll compaction
dry granulation
mannitol
dicalcium phosphate
design of experiments
orthogonal projections to latent structures
critical quality attributes
tablet manufacturing
quality by design
design space
near-infrared chemical imaging
texture analysis
modeling
scale up
instrumented roll
Johanson model
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96441
http://nbn-resolving.de/urn:isbn:978-91-7601-162-1

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96441
http://nbn-resolving.de/urn:isbn:978-91-7601-162-1

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