Determination of Cisplatin using Hydrophilic Interaction Liquid Chromatography (HILIC) Coupled with Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Study on Cisplatin’s Retention Mechanisms in HILIC and Uptake and Intracellular Decay Kinetics in in-vitro Grown Cells
Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is widely used for the treatment of several solid tumors. The antitumor property of cisplatin is generally proved that the covalent binding of cisplatin to DNA distorts the DNA structure, which leads to the death of the cancer cells. The obstacle fo...
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| Format: | Others |
| Language: | English |
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Umeå universitet, Kemiska institutionen
2012
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-56554 |