Anaplastic Lymphoma Kinase mutations and downstream signalling

Anaplastic Lymphoma Kinase mutations and downstream signalling

The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. Further, o...

Full description

Bibliographic Details
Main Author: Schönherr, Christina
Format: Doctoral Thesis
Language:English
Published: Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten) 2012
Subjects:
Anaplastic Lymphoma Kinase
oncogene
RTK
neuroblastoma
crizotinib
NVP-TAE684
gain-of-function
MYCN
transcription factor
small GTPase
Rap1
C3G
PC12 cells
neurite outgrowth
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54562
http://nbn-resolving.de/urn:isbn:978-91-7459-387-7

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54562
http://nbn-resolving.de/urn:isbn:978-91-7459-387-7

Similar Items