Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell recepto...

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Bibliographic Details
Main Author: Andersson, Ida E.
Format: Doctoral Thesis
Language:English
Published: Umeå universitet, Kemiska institutionen 2011
Subjects:
Major histocompatibility complex
class II MHC
T-cell receptor
rheumatoid arthritis
collagen-induced arthritis
glycopeptide
amide bond isostere
comparative modeling
rational design
molecular docking
molecular dynamics simulation
statistical molecular design
Bioorganic chemistry
Bioorganisk kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42082
http://nbn-resolving.de/urn:isbn:978-91-7459-173-6

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42082
http://nbn-resolving.de/urn:isbn:978-91-7459-173-6

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