Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS

Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS

Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. Overexpression of human mutant or wild type SOD1 in transgenic mouse models...

Full description

Bibliographic Details
Main Author: Forsgren, Elin
Format: Doctoral Thesis
Language:English
Published: Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap 2017
Subjects:
ALS
SOD1
patient-derived models
induced pluripotent stem cells
motor neurons
astrocytes
20S proteasome low oxygen tension
misfolded SOD1
Natural Sciences
Naturvetenskap
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138948
http://nbn-resolving.de/urn:isbn:978-91-7601-759-3

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138948
http://nbn-resolving.de/urn:isbn:978-91-7601-759-3

Similar Items