Zinc in folding and misfolding of SOD1 : Implications for ALS

Zinc in folding and misfolding of SOD1 : Implications for ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing degeneration of upper and lower motor neurons. Most ALS cases are sporadic; only 6% are associated with mutations in Cu, Zn superoxide dismutase (SOD1). It is believed, however, that sporadic and familiar forms of ALS share a...

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Bibliographic Details
Main Author: Leinartaité, Lina
Format: Doctoral Thesis
Language:English
Published: Stockholms universitet, Institutionen för biokemi och biofysik 2014
Subjects:
protein stability
protein misfolding
local unfolding
metal binding
energy landscape
protein disease
amyotrophic lateral sclerosis
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-107543
http://nbn-resolving.de/urn:isbn:978-91-7447-939-3

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-107543
http://nbn-resolving.de/urn:isbn:978-91-7447-939-3

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