Genetic Variations in the NLRP3 Inflammasome : Susceptibility Factor for Chronic Inflammation
NLRP3 has been recognized as one of the key components of innate immunity. Upon activation, NLRP3 forms a multiprotein complex called as the ‘inflammasome’ which leads to the activation of pro-inflammatory caspase-1 which subsequently results in the formation of Interleukin (IL)-1β and IL-18. Mutati...
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| Format: | Doctoral Thesis |
| Language: | English |
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Linköpings universitet, Cellbiologi
2011
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70077 http://nbn-resolving.de/urn:isbn:978-91-7393-116-8 |