Catalysis and Site-Specific Modification of Glutathione Transferases Enabled by Rational Design
This thesis describes the rational design of a novel enzyme, a thiolester hydrolase, derived from human glutathione transferase (GST) A1-1 by the introduction of a single histidine residue. The first section of the thesis describes the design and the determination of the reaction mechanism. The desi...
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| Format: | Doctoral Thesis |
| Language: | English |
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Linköpings universitet, Organisk Kemi
2005
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-3962 http://nbn-resolving.de/urn:isbn:91-85457-09-4 |