Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase
Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. Thiopurines are used in inflammatory bowel disease, as maintenance t...
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| Format: | Doctoral Thesis |
| Language: | English |
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Linköpings universitet, Klinisk farmakologi
2005
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-30560 http://nbn-resolving.de/urn:isbn:91-85299-01-4 |