Identifying Pathogenic Amino Acid Substitutions in Human Proteins Using Deep Learning

Identifying Pathogenic Amino Acid Substitutions in Human Proteins Using Deep Learning

Many diseases of genetic origin originate from non-synonymous single nucleotide polymorphisms (nsSNPs). These cause changes in the final protein product encoded by a gene. Through large scale sequencing and population studies, there is growing availability of information of which variations are tole...

Full description

Bibliographic Details
Main Author: Kvist, Alexander
Format: Others
Language:English
Published: KTH, Skolan för kemi, bioteknologi och hälsa (CBH) 2018
Subjects:
Bioinformatics
deep learning
proteomics
mutations
single nucleotide polymorphism
SNP
convolutional neural network
variant effect prediction
Medical Engineering
Medicinteknik
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-233513

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-233513

Similar Items