Structural and Mechanistic Studies of alpha-galactosidase A and Pharmacological Chaperones
Human α-galactosidase (α-GAL; EC 3.2.1.22) is a lysosomal enzyme that hydrolyzes of terminal alpha-linked galactosyl residue of glycosphingolipids. Deficiencies in α-GAL leads to Fabry disease, which is characterized by the build-up of globotriaosylceramide and other neutral substrates in cells, ult...
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ScholarWorks@UMass Amherst
2010
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| Online Access: | https://scholarworks.umass.edu/open_access_dissertations/202 https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1202&context=open_access_dissertations |