Controlling salmonella accumulation inside solid tumors via bacterial chemotaxis engineering and combined treatment with lipid A
Most chemotherapeutics fail to treat solid tumors because they cannot reach beyond regions proximal to blood vessels and are ineffective against quiescent tumor cells. Motile Salmonella typhimurium, being able to penetrate tumor tissue and chemotax towards distant tumor regions, provides an attracti...
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| Language: | ENG |
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ScholarWorks@UMass Amherst
2012
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| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3546051 |