The role of the Suprmam1 locus in responses to ionizing radiation and susceptibility to mammary tumors
Loss of p53 function can lead to a variety of cancers, including breast cancer. Mice heterozygous for the p53 gene (designated Trp53 +/−) develop spontaneous mammary tumors, but this depends on the strain background and has been linked to a locus on chromosome 7 (designated SuprMam1). Mammary tumors...
| Main Author: | |
|---|---|
| Language: | ENG |
| Published: |
ScholarWorks@UMass Amherst
2011
|
| Subjects: | |
| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3465002 |